![]() Other parameters of iron metabolism, including ferritin, were not found to contribute to the risk. This study suggests that transferrin, measured as TIBC, is an independent negative risk factor for myocardial infarction. Sex was in this group still a very strong risk factor after taking into account all classic risk factors as well as the parameters of iron metabolism. When Cox multivariate analysis was carried out on both sexes combined, TIBC was still an independent negative risk factor, and the logarithmic transform of ferritin had a weak negative correlation but was not statistically significant. The classic major risk factors, ie, blood pressure, smoking, total cholesterol, and high-density lipoprotein, had significant independent correlation with myocardial infarction. All crossword answers with 7 Letters for Number denoting an ions bonding capacity found in daily crossword puzzles: NY Times, Daily Celebrity, Telegraph. ![]() Each increase in TIBC of 1 mumol/L was associated with a 5.1% decrease in the risk of myocardial infarction. High levels of TIBC and transferrin indicate high levels of iron binding capacity in other words, your body has a lot of feelers out for iron to absorb and you should increase your intake of iron.3,11 Normal ferritin levels with normal TIBC levels is a good indication that you are likely meeting your iron needs, regardless of inflammation. TIBC was found to be a strong independent negative risk factor in men (RR = 0.95 95% CI, 0.92 to 0.98), whereas ferritin (RR = 0.999 95% CI, 0.997 to 1.001) or other iron parameters had no significant predictive power. The Cox proportional hazards model was used to estimate the contribution of independent variables to the risk of myocardial infarction. The differences in the iron parameters between men and women were almost exclusively seen in ferritin values (198 micrograms/L in men and 91 micrograms/L in women), whereas small differences were seen in TIBC. During the follow-up for 8.5 years, 81 subjects experienced acute myocardial infarction (63 men and 18 women). All classic risk factors for coronary artery disease were measured as well as basic hematologic parameters and the parameters of iron metabolism, ie, iron, total iron-binding capacity (TIBC), and ferritin. This is unsaturated iron-binding capacity. As only one-third of transferrin is saturated with iron, so the transferrin present in serum has an extra binding capacity (67). When iron stores are depleted, the transferrin levels increase in the blood. This study suggested that high levels of iron stores might thus be atherogenic and possibly explain partly the sex difference in the incidence of ischemic heart disease.Ī randomly selected group (n = 2036), men and women aged 25 to 74 years, were examined between June and September 1983. Iron binding capacity is of two types, TIBC and unsaturated iron-binding capacity (UIBC). In a recent Finnish study, ferritin was suggested to be an independent risk factor for acute myocardial infarction.
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